For which diseases can PGT-M be performed?
- Monogenic conditions are those that are caused by mutations in a single gene, rather than by several different genetic and environmental factors.
- These conditions may have autosomal dominant,autosomal recessive, X-linked, or mitochondrial inheritance.
- PGT-M, formerly single gene PGD, is available for the vast majority of serious genetic conditions, as long as the particular gene mutation(s) in the family have been identified through DNA testing.
- However, the ability to offer PGT-M is dependent not only on the disorder/gene itself but also on the ability to successfully offer
a reliable test using available technologies.
Consulting documents
Consulting documents:
Prospective parents receive counseling with GeneCare and discuss, if necessar y, additional genetic tests of the couple or family members.
Prepare PGT-M:
PGT-M Gene Care will design a unique procedure for each family.
IVF:
Embryo are generated through an IVF cycle
Embryo biopsy:
Some carefully biopsied cells from the embryo develop into the placenta. These cekks are sent to the Gene Care while your embr yo remains safe at the IVF center
PGT-M:
The embryo bicpsy samples were sent to PCT-M Gene Care. That family specifie precedure will follow the workpiece sample and the result will be sent back to your IVF center.
Transfer of workpieces:
On Gene Care’s analysis report. Your medical team will select the embryos with the best results for transfer. The embryos can be frozen for future use.
Consultation with our counseling board.
- Genetic testing to identify the specific disease mutation in the family (if not already done)
- Fertility testing.
- PGT-M custom test development (often referred to as “making a probe”).
- In Vitro Fertilization: embryos are created and grown to the blastocyst stage (day 5 or 6).
- Trophectoderm biopsy of ~5-10 cells from the future placental cells of each embryo.
- Embryos are frozen.
- Cells removed from the embryos are tested for the single gene condition, as well as for sporadic chromosome problems.
- Results available.
- Transfer embryos to uterus of patient or surrogate in a subsequent frozen embryo transfer cycle.
- Extra embryos remain frozen for future use.
