For which diseases can PGT-M be performed?

  • Monogenic conditions are those that are caused by mutations in a single gene, rather than by several different genetic and environmental factors.
  • These conditions may have autosomal dominant,autosomal recessive, X-linked, or mitochondrial inheritance.
  • PGT-M, formerly single gene PGD, is available for the vast majority of serious genetic conditions, as long as the particular gene mutation(s) in the family have been identified through DNA testing.
  • However, the ability to offer PGT-M is dependent not only on the  disorder/gene  itself  but  also  on  the  ability  to  successfully  offer
    a reliable test using available technologies.

Consulting documents

Consulting documents:

Prospective parents receive counseling with GeneCare and discuss, if necessar y, additional genetic tests of the couple or family members.

Prepare PGT-M:

PGT-M Gene Care will design a unique procedure for each family.

Embryo are generated through  an IVF cycle
Embryo biopsy:

Some carefully  biopsied cells from the embryo develop  into the placenta. These cekks are sent to the Gene Care while your embr yo remains  safe at the  IVF center


The embryo bicpsy samples were sent to PCT-M Gene Care. That family specifie precedure will follow the workpiece sample and the result will be sent back to your IVF center.

Transfer of workpieces:

On Gene Care’s  analysis report. Your medical team will select the embryos with the best results for transfer. The embryos  can be frozen for future use.

Consultation with our counseling board.

  1. Genetic testing to identify the specific disease mutation in the family (if not already done)
  2. Fertility testing.
  3. PGT-M custom test development (often referred to as “making a probe”).
  4. In Vitro Fertilization: embryos are created and grown to the blastocyst stage (day 5 or 6).
  5. Trophectoderm biopsy of ~5-10 cells from the future placental cells of each embryo.
  6. Embryos are frozen.
  7. Cells removed from the embryos are tested for the single gene condition, as well as for sporadic chromosome problems.
  8. Results available.
  9. Transfer embryos to uterus of patient or surrogate in a subsequent frozen embryo transfer cycle.
  10. Extra embryos remain frozen for future use.